TABLE 3.
Top 10 predicted transcription factors of hub genes by TRRUST.
| Rank | Key TF | Description | Target genes | P-value | FDR |
| 1 | RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | BGN, CCL2, F3, FN1, GFAP, TIMP1, VWF | 1.59E-08 | 1.41E-07 |
| 2 | NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | BGN, CCL2, F3, FN1, GFAP, TIMP1, VWF | 1.66E-08 | 1.41E-07 |
| 3 | NFIC | Nuclear factor I/C (CCAAT- binding transcription factor) | CCL2, GFAP, VWF | 2.93E-06 | 1.66E-05 |
| 4 | TWIST1 | Twist basic helix-loop-helix transcription factor 1 | CD44, FN1, TIMP1 | 6.52E-06 | 2.32E-05 |
| 5 | SP1 | Sp1 transcription factor | APOE, CCL2, CD44, F3, SOX9, TIMP1 | 6.81E-06 | 2.32E-05 |
| 6 | EGR1 | Early growth response 1 | F3, FLT1, FN1 | 0.000105 | 0.000299 |
| 7 | REL | v-rel reticuloendotheliosis viral oncogene homolog (avian) | CCL2, F3 | 0.000243 | 0.000591 |
| 8 | TWIST2 | Twist basic helix-loop-helix transcription factor 2 | CD44, FN1 | 0.000316 | 0.000671 |
| 9 | ERG | v-ets erythroblastosis virus E26 oncogene homolog (avian) | CDH5,VWF | 0.000369 | 0.000696 |
| 10 | STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | CCL2, GFAP, TIMP1 | 0.000433 | 0.000736 |