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. Author manuscript; available in PMC: 2020 Nov 23.
Published in final edited form as: Biochem Pharmacol. 2019 Aug 14;169:113604. doi: 10.1016/j.bcp.2019.08.006

Figure 6: Changes in Coproporphyrinogen and Uroporphyrinogen levels in urine samples from CSE−/− and wild-type mice.

Figure 6:

Urine samples from CSE−/− (n=9) and wild-type (n=11) mice were collected using metabolic cages overnight (16 hours). For each sample, creatinine content was determined (Creatinine Colorimetric Assay, BioVision). The measured porphyrins were normalized to urine creatinine for each sample. Data demonstrates reduced tendency of total coproporphyrinogen (A) and significantly increased uroporphyrinogen (B) in urine samples from CSE−/− mice suggesting upregulated activity of CPOX enzyme. Data are shown as mean ± SEM of coproporphyrinogen and uroporphyrinogen concentrations normalized to urine creatinine content. *p<0.05 vs. wild-type group.