Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
RPA bound to a pre-formed 5'-flap is sufficient to bypass FEN1 inhibition and favor the Pif1-dependent stimulation of DNA synthesis through a protein barrier. A, quantification of primer extension assays performed using Pol δWT with a Reb1-bound substrate with a preformed 5'-flap, the presence or absence of FEN1 and Pif1. B, same as A, but in the presence of RPA. The error bars are the mean ± S.D. from 3 independent replicates.
