FIGURE 4.

Chronic treatment with low doses of rosiglitazone alters the levels of expression of genes involved in inflammatory responses and in mitochondrial functionality. (a) Percentage of differentially expressed genes (DEGs) in adipose tissues, liver, muscle and brain in 20‐month‐old mice after they were treated for 6 months. (b, c) Distribution of modulated genes in different pathways and tissues. (d) Expression levels of representative genes of each category in multiple organs of 20‐month‐old mice after 6 months of treatment. Data are presented as mean ± SEM and Student t tests were performed to compare control and Rosi‐treated group (*p < 0.05, **p < 0.01, n = 6 per group)