FIGURE 5.

Limited adverse effects of long‐term rosiglitazone treatment at the low dose of 1 mg/kg/day on water retention, heart functionality, and bone density. (a–f) Analysis of 17‐month‐old mice after they were treated for 3 months with either control diet or Rosi‐containing diet (1 mg/kg/day) (n = 6). (a) Water content. (b, c) Heart weight and representative images of Wheat Germ Agglutinin (WGA) staining of heart. (d–g) Measurements of heart functionality include hemodynamics, left ventricular (LV) structure, LV function and LV outflow tract. (h) Representative images of femurs by X rays, (i) comparison of femur length, (j) measurements of X‐ray density, (k) micro‐CT reconstruction, and (l) parameters of trabecular and cortical bone. Data are presented as mean ± SEM