TABLE 1.

Serum parameter analysis of control‐ and Rosi‐treated mice

Tests	CON	ROSI	p
Minerals
Sodium (mmol/L)	157.0 ± 6.6	151.7 ± 4.6	0.13
Potassium (mmol/L)	9.95 ± 0.12	9.11 ± 1.42	0.19
Chloride (mmol/L)	116.2 ± 6.49	111.5 ± 7.79	0.29
Calcium (mmol/L)	2.31 ± 0.18	2.36 ± 0.14	0.59
Magnesium (mmol/L)	1.76 ± 0.31	1.56 ± 0.11	0.16
Phosphorus, inorganic (mg/dL)	9.48 ± 3.31	8.65 ± 1.64	0.59
Glucose (mg/dL)	152.2 ± 29.24	120.0 ± 14.17	0.03*
Lipids
Total cholesterol (mg/dL)	87.0 ± 15.91	83.0 ± 24.23	0.67
Triglycerides (mg/dL)	37.0 ± 19.91	33.3 ± 10.84	0.71
Renal/proteins
Urea nitrogen (BUN, mg/dL)	32.0 ± 9.96	30.0 ± 5.14	0.52
Creatinine (mg/dL)	0.35 ± 0.05	0.30 ± 0.31	0.95
Uric acid (mg/dL)	5.16 ± 2.56	4.30 ± 1.92	0.83
Albumin (g/dL)	3.08 ± 0.29	3.10 ± 0.61	0.74
Total protein (g/dL)	4.43 ± 0.49	4.52 ± 0.79	0.70
Enzymes
Alkaline phosphatase (U/L)	120.2 ± 26.5	126.5 ± 49.3	0.78
Alanine aminotransferase (ALT, U/L)	38.67 ± 17.85	44.67 ± 16.31	0.55
Aspartate aminotransferase (AST, U/L)	115.50 ± 34.57	131.33 ± 48.91	0.41
Amylase (U/L)	3596.3 ± 1601.5	2879.0 ± 572.7	0.32
Creatine kinase (U/L)	1424.8 ± 471.9	1251.0 ± 307.9	0.46
Lactate dehydrogenase (U/L)	774.0 ± 276.07	695.7 ± 411.1	0.71

Student t tests were performed to compare serum parameters of control‐ or Rosi‐treated mice of 20 months of age after 6 months of treatment. N = 6 per group. * symbol is used to highlight statistically significant values