TABLE 1.
Tests | CON | ROSI | p |
---|---|---|---|
Minerals | |||
Sodium (mmol/L) | 157.0 ± 6.6 | 151.7 ± 4.6 | 0.13 |
Potassium (mmol/L) | 9.95 ± 0.12 | 9.11 ± 1.42 | 0.19 |
Chloride (mmol/L) | 116.2 ± 6.49 | 111.5 ± 7.79 | 0.29 |
Calcium (mmol/L) | 2.31 ± 0.18 | 2.36 ± 0.14 | 0.59 |
Magnesium (mmol/L) | 1.76 ± 0.31 | 1.56 ± 0.11 | 0.16 |
Phosphorus, inorganic (mg/dL) | 9.48 ± 3.31 | 8.65 ± 1.64 | 0.59 |
Glucose (mg/dL) | 152.2 ± 29.24 | 120.0 ± 14.17 | 0.03* |
Lipids | |||
Total cholesterol (mg/dL) | 87.0 ± 15.91 | 83.0 ± 24.23 | 0.67 |
Triglycerides (mg/dL) | 37.0 ± 19.91 | 33.3 ± 10.84 | 0.71 |
Renal/proteins | |||
Urea nitrogen (BUN, mg/dL) | 32.0 ± 9.96 | 30.0 ± 5.14 | 0.52 |
Creatinine (mg/dL) | 0.35 ± 0.05 | 0.30 ± 0.31 | 0.95 |
Uric acid (mg/dL) | 5.16 ± 2.56 | 4.30 ± 1.92 | 0.83 |
Albumin (g/dL) | 3.08 ± 0.29 | 3.10 ± 0.61 | 0.74 |
Total protein (g/dL) | 4.43 ± 0.49 | 4.52 ± 0.79 | 0.70 |
Enzymes | |||
Alkaline phosphatase (U/L) | 120.2 ± 26.5 | 126.5 ± 49.3 | 0.78 |
Alanine aminotransferase (ALT, U/L) | 38.67 ± 17.85 | 44.67 ± 16.31 | 0.55 |
Aspartate aminotransferase (AST, U/L) | 115.50 ± 34.57 | 131.33 ± 48.91 | 0.41 |
Amylase (U/L) | 3596.3 ± 1601.5 | 2879.0 ± 572.7 | 0.32 |
Creatine kinase (U/L) | 1424.8 ± 471.9 | 1251.0 ± 307.9 | 0.46 |
Lactate dehydrogenase (U/L) | 774.0 ± 276.07 | 695.7 ± 411.1 | 0.71 |
Student t tests were performed to compare serum parameters of control‐ or Rosi‐treated mice of 20 months of age after 6 months of treatment. N = 6 per group. * symbol is used to highlight statistically significant values