TABLE 2.
Heart parameters measured by Echo MRI
| CON | TZD | p value | |
|---|---|---|---|
| Hemodynamics | |||
| Heart rate, bpm | 478.33 ± 33.13 | 485 ± 18.06 | 0.67 |
| Left ventricular (LV) structure | |||
| Volume; systole, ul | 19.23 ± 8.74 | 23.36 ± 4.52 | 0.31 |
| Volume; diastole, ul | 60.65 ± 28.22 | 68.51 ± 5.96 | 0.52 |
| Diameters; systole, mm | 2.43 ± 0.21 | 2.60 ± 0.22 | 0.23 |
| Diameters; diastole, mm | 3.96 ± 0.23 | 4.04 ± 0.23 | 0.55 |
| LV anterior wall; systole, mm | 1.37 ± 0.02 | 1.36 ± 0.02 | 0.94 |
| LV anterior wall; diastole, mm | 0.92 ± 0.04 | 0.92 ± 0.05 | 0.73 |
| LV posterior wall; systole, mm | 1.34 ± 0.03 | 1.30 ± 0.05 | 0.27 |
| LV posterior wall; diastole, mm | 0.91 ± 0.03 | 0.91 ± 0.04 | 0.88 |
| LV function | |||
| Ejection fraction (EF, %) | 69.25 ± 5.41 | 65.93 ± 2.49 | 0.30 |
| Fractional shortening (FS, %) | 38.53 ± 4.25 | 35.66 ± 2.13 | 0.28 |
| Left Ventricular outflow tract | |||
| Peak grad, mmHg | 9.07 ± 1.77 | 8.48 ± 6.69 | 0.84 |
| Peak velocity, mm/s | 1499.83 ± 153.2 | 1390.4 ± 489.86 | 0.61 |
Student t tests were performed to compare heart parameters in 17‐month‐old mice after they were treated with Rosi or control for 3 months, starting at 14 months of age. N = 6 per group.