Figure 1.

Multiple variations of long exosomal RNAs in different cancer types. (A) Multiple variations of long exRNAs identified in three cancer types (CRC: colorectal cancer, HCC: hepatocellular carcinoma, PAAD: pancreatic adenocarcinoma) using healthy donors as control. The dark blue and light blue indicate the opposite pattern of RNA variations, including differential expression, alternative splicing (AS), alternative polyadenylation (APA), and differential editing. FC: fold-change, FDR: false discovery rate, PSI: percent spliced in index, UTR: untranslated region. (B) Numbers of differentially expressed RNAs for different RNA types. up: up-regulation, dn: down-regulation. (C) Overlap of differential expression, alternative splicing, alternative polyadenylation, differential editing events among three types of cancer. (D) List of common differential expression, alternative splicing, and differential editing events among three cancer types.