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. 2021 Jan 1;11(1):181–193. doi: 10.7150/thno.48206

Figure 7.

Figure 7

Detection panel of 3 noncoding RNAs for the AFP-negative and early-stage liver cancer. (A) Workflow chart of identifying a 3-RNA panel for detecting liver cancer in plasma. Rectangular box indicates the type and quantity of RNA variation. Diamond indicates the screening method and cut-off. (B) Performance of the 3-RNA panel (SNORD3B-1, circ-0080695, miR-122) in training, testing and validation sets (model: Random Forest). Trained on alpha feto-protein (AFP) positive (AFP > 400 ng/ml) patients (HCCs), Chronic hepatitis B patients (CHBs) and healthy donors (HDs); tested and validated on AFP negative (AFP < 400 ng/ml) patients (HCCs). *: early stages (0/A) are labeled in red. NA: Not available. (C) Predicted values of the 3-RNA panel (model: Random Forest). The cutoff of the predicted value is defined by requiring > 95% specifity of healthy donors in the training set. Triangle points represent patients with 20 ng/ml < AFP ≤ 400 ng/ml. Red points represent patients of early stages (0/A).