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Treatment with 177Lu-DOTA-Y003 increases tumor-infiltrating lymphocytes and upregulates PD-L1 expression in tumors. A. Percentage of PD-L1 neoplastic cells (CD45-/PD-L1), CD8+ T cells, CD4+ T cells and regulatory T cells in tumors after the indicated treatment. B. Representative fluorescent images of the immunofluorescence staining of tumors.
