Table 2.
Clinical value of tRFs in cancers and virus infections
| Function | Sample type | tRF name/ID | Cancer type/Virus infection | References |
|---|---|---|---|---|
| Potential diagnostic and prognostic predictive utility | Plasma (exosome) | tRF-5GluCTC | Liver cancer | 66 |
| Serum | tRF-30-JZOYJE22RR33, tRF-27-ZDXPHO53KSN | Breast cancer | 67 | |
| Blood (peripheral blood mononuclear cells) | i-tRF-GlyCCC, i-tRF-GlyGCC, i-tRF-PheGAA | Chronic lymphocytic leukemia | 68-70 | |
| Tissue | tRF-315, tRF-544 | Prostate cancer | 71 | |
| Potential clinical therapeutic targets | Cell, serum, patient-derived xenograft model | 3′tRF-LeuCAG | Hepatocellular carcinoma | 45 |
| Cell, virus | tRF-5GluCTC | Respiratory syncytial virus infection | 63 |