Table II.
lncRNAs associated with the regulation of miR-497 expression in cancer.
| Cancer type | lncRNA | Expression | Targets | Type of interaction | Biological functions | (Refs.) |
|---|---|---|---|---|---|---|
| Gastric cancer | XIST | Upregulated | miR-497, MACC1 | Neg | Promotes cell cycle progression | (64) |
| GACAT-3 | Upregulated | miR-497 | Neg | Promotes cancer progression | (68) | |
| LINC-00662 | Upregulated | miR-497, YAP1 | Neg | Promotes cell proliferation | (74) | |
| LINC-00978 | Upregulated | miR-497, NTRK3 | Neg | Promotes cell proliferation and tumorigenesis | (76) | |
| NEAT1 | Upregulated | miR-497, PIK3R1 | Neg | Promotes cell proliferation | (70) | |
| Osteosarcoma | PVT1 | Upregulated | miR-497, HK2 | Neg | Promotes glucose metabolism, cell proliferation | (66) |
| Non-small cell lung cancer | PVT1 | Upregulated | miR-497 | Neg | Promotes tumorigenesis | (67) |
| SNHG1 | Upregulated | miR-497, IGF1-R | Neg | Promotes cancer progression | (78) | |
| Breast cancer | GACAT-3 | Upregulated | miR-497, CCND2 | Neg | Promotes cell proliferation | (69) |
| HOXC13-AS | Upregulated | miR-497, PTEN | Neg | Promotes cell proliferation | (84) | |
| LINC-00473 | Upregulated | miR-497 | Neg | Acts as a tumor promoter | (86) | |
| Thyroid carcinoma | LINC-00152 | Upregulated | miR-497, BDNF | Neg | Promotes cell proliferation and invasion | (71) |
| SNHG16 | Upregulated | miR-497 | Neg | Drives proliferation and invasion | (81) | |
| Multiple myeloma | LINC-00152 | Upregulated | miR-497 | Neg | Promotes cancer progression | (72) |
| Adrenocortical carcinoma | MALAT-1 | Upregulated | miR-497 | Feedback axis | Promotes tumorigenesis | (89) |
| Pancreatic cancer | DLX6-AS1 | Upregulated | miR-497, FZD4, FZD6, Wnt, β-catenin | Neg | Promotes tumorigenesis | (91) |
| LINC-00339 | Upregulated | miR-497, IGF1-R | Neg | Promotes cell proliferation and metastasis | (92) | |
| LINC-01410 | Upregulated | miR-497, IFITM3 | Neg | Promotes cell proliferation and metastasis | (94) | |
| Colorectal cancer | SNHG1 | Upregulated | miR-497 | Neg | Promotes EMT | (79) |
| AC-009022.1 | Upregulated | miR-497, ACTR3B | Neg | Promotes cell proliferation, migration and invasion | (95) | |
| Hepatocellular carcinoma | XIST | Downregulated | miR-497, PDCD4 | Neg | Participates in cancer development | (55) |
| Diffuse large B-cell lymphoma | SNHG16 | Upregulated | miR-497, PIM1 | Neg | Promotes cell proliferation and inhibits apoptosis | (82) |
| Esophageal squamous cell carcinoma | LINC-00473 | Upregulated | miR-497, PRKAA1 | Neg | Promotes cell proliferation and metastasis | (87) |
| Laryngeal squamous cell cancer | CDKN2B-AS1 | Upregulated | miR-497, CDK6 | Neg | Promotes cell proliferation and metastasis | (96) |
Neg, negative; lncRNA, long non-coding RNA; miR, miRNA.