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. 2020 Nov 3;21(1):8. doi: 10.3892/ol.2020.12269

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Copyright: © Lou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Differential GADD45A methylation status and radiosensitivity of the three CC cell lines. (A) Radiosensitivity was assessed in CaSki, HeLa and SiHa cells, and determined via a colony formation assay, by measuring the cells as the survival fraction following treatment with 2 Gy radiation. High GADD45A (B) mRNA and (C) protein expression levels were associated with cellular sensitivity to radiation in CC cells. (D) Aberrant methylation of the GADD45A promoter was associated with decreased radiosensitivity in CC cells. *P<0.05, ***P<0.001. CC, cervical cancer; NS, not significant; M, methylated; U, unmethylated.