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. 2020 Nov 3;21(1):8. doi: 10.3892/ol.2020.12269

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Copyright: © Lou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — PI3K/AKT signaling pathway is essential for radioresistance, which is mediated by downregulation of GADD45A. (A) Phosphorylation levels of AKT were downregulated by GADD45A. (B) MK-2206 inhibited phosphorylation of AKT at Ser 473. (C) MK-2206 enhanced the radiosensitivity of SiHa cells. The colony formation assay was performed to assess the radiosensitivity of SiHa cells. (D) Flow cytometric analysis demonstrated that MK-2206 did not significantly affect the cell cycle distribution. **P<0.01. Vec, vector; NS, not significant.