Table I.
Frequency of tumor infiltration into the submucosal layer and invasion into vessels in azoxymethane/dextran sodium sulfate mice.
| Weeks | Submucosal infiltration, positive | Vessel invasion, positive |
|---|---|---|
| Week 10 | 6/25 (24%)a,b | 0/25 (0%)a,c |
| Week 20 | 7/25 (28%)b | 1/25 (4%)b |
| Week 30 | 18/25 (72%) | 10/25 (40%) |
a
n.s. vs. week 20
b
P<0.01 vs. week 30
c
P<0.001 vs. week 30. Data were analyzed using a Kruskal-Wallis test followed by Mann-Whitney U test with Bonferroni correction. n.s., not significant.