| Author and Year of Publication |
Type of Study |
Number of Patients |
Comparator |
Study Length |
Conclusion/Result |
| Lunney P C et al., 2012 [10] |
Review |
374 (72) |
placebo |
Six weeks |
The concentrations of nicotine and cotinine in the blood were lower than expected throughout the study in patients of the nicotine group, suggesting poor compliance to therapy. |
| Pullan R D et al., 1994 [17] |
Randomized control trial |
72 |
placebo |
Six weeks |
The addition of transdermal nicotine to conventional maintenance therapy improves symptoms in patients with ulcerative colitis. |
| Sandborn W J et al., 1997 [16] |
Randomized control trial |
64 |
Placebo |
Four weeks |
Highest tolerated dosage, i.e. 22 g/d or more for four weeks, is considered best for controlling the manifestations of the disease. |
| Richardson C E et al, 2003 [11] |
Observational Study |
160 (43) |
placebo |
26 weeks |
The intensity or distribution of epithelial staining did not vary before and after treatment with a nicotine patch. |
