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. 2020 Nov 23;21:947. doi: 10.1186/s13063-020-04842-w

Table 1.

Dosing schedule for study medications

Group: NTX VAR PLA
Day: AM PM AM PM AM PM
Medication titration
 1 1 capsule (12.5 mg NTX) 1 capsule (placebo) 1 capsule (0.5 mg VAR) 1 capsule (placebo) 1 capsule (placebo) 1 capsule (placebo)
 2 1 capsule (12.5 mg NTX) 1 capsule (placebo) 1 capsule (0.5 mg VAR) 1 capsule (placebo) 1 capsule (placebo) 1 capsule (placebo)
 3 1 capsule (12.5 mg NTX) 1 capsule (placebo) 1 capsule (0.5 mg VAR) 1 capsule (placebo) 1 capsule (placebo) 1 capsule (placebo)
 4 1 capsule (25 mg NTX) 1 capsule (placebo) 1 capsule (0.5 mg VAR) 1 capsule (0.5 mg VAR) 1 capsule (placebo) 1 capsule (placebo)
 5 1 capsule (25 mg NTX) 1 capsule (placebo) 1 capsule (0.5 mg VAR) 1 capsule (0.5 mg VAR) 1 capsule (placebo) 1 capsule (placebo)
 6 1 capsule (25 mg NTX) 1 capsule (placebo) 1 capsule (0.5 mg VAR) 1 capsule (0.5 mg VAR) 1 capsule (placebo) 1 capsule (placebo)
 7 1 capsule (25 mg NTX) 1 capsule (placebo) 1 capsule (0.5 mg VAR) 1 capsule (0.5 mg VAR) 1 capsule (placebo) 1 capsule (placebo)
Practice quit attempt
 8 1 capsule (50 mg NTX) 1 capsule (placebo) 1 capsule (1 mg VAR) 1 capsule (1 mg VAR) 1 capsule (placebo) 1 capsule (placebo)
 9 1 capsule (50 mg NTX) 1 capsule (placebo) 1 capsule (1 mg VAR) 1 capsule (1 mg VAR) 1 capsule (placebo) 1 capsule (placebo)
 10 1 capsule (50 mg NTX) 1 capsule (placebo) 1 capsule (1 mg VAR) 1 capsule (1 mg VAR) 1 capsule (placebo) 1 capsule (placebo)
 11 1 capsule (50 mg NTX) 1 capsule (placebo) 1 capsule (1 mg VAR) 1 capsule (1 mg VAR) 1 capsule (placebo) 1 capsule (placebo)
 12 1 capsule (50 mg NTX) 1 capsule (placebo) 1 capsule (1 mg VAR) 1 capsule (1 mg VAR) 1 capsule (placebo) 1 capsule (placebo)
 13 1 capsule (50 mg NTX) 1 capsule (placebo) 1 capsule (1 mg VAR) 1 capsule (1 mg VAR) 1 capsule (placebo) 1 capsule (placebo)
 14 1 capsule (50 mg NTX) – 1 capsule (1 mg VAR) – 1 capsule (placebo) –