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. 2020 Nov 23;19:164. doi: 10.1186/s12943-020-01272-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Circ-ERBIN knockdown suppresses CRC cells proliferation, migration and invasion in vitro and in vivo. a Transwell migration assays in HCT116 and RKO cells after circ-ERBIN siRNAs transfection. b-d CCK8, EdU and colony formation assays in HCT116 cells after circ-ERBIN knockdown. e HCT116 sh-circ-ERBIN stable cells were analyzed for their in vitro migration and invasion using transwell chambers and invasion chambers, respectively. f-g HCT116 sh-circ-ERBIN stable cells were injected into BALB/C nude mice (n = 6 for each group). Tumor volumes and weights were monitored. h The number of metastases in mice injected with sh-circ-ERBIN #1/#3 stable cells through tail vein into nude mice to produce lung metastasis model of CRC. Images of H&E staining (Left) are shown and tumor area was measured (Right). Data are means ± SD. * and #, P<0.05 vs LV3 or Oligo