Table 1.

Relation of WNT4, CA199, CEA expression with clinicopathological parameters of patients with CRC

Parameters	WNT4 (pg/mL)		P value	CA199 (U/mL)		P value	CEA (ng/mL)		P value
	Cases	Mean ± SEM		Cases	Mean ± SEM		Cases	Mean ± SEM
Age(y)
≤ 65	23	77.31 ± 10.04	0.9583	22	31.51 ± 10.27	0.3766	22	4.304 ± 1.315	0.7307
> 65	17	78.07 ± 9.623		16	19.78 ± 5.963		16	3.671 ± 1.143
Sex
Male	20	88.46 ± 11.14	0.1129	19	28.36 ± 9.941	0.7862	19	4.445 ± 1.394	0.6533
Female	20	66.81 ± 7.998		19	24.79 ± 8.484		19	3.629 ± 1.141
TNM T
I ∼ II	13	55.94 ± 8.395	0.0293	13	26.84 ± 12.39	0.9768	12	1.135 ± 0.237	0.0247
III ∼ IV	27	88.08 ± 8.941		25	26.44 ± 7.594		26	5.377 ± 1.216
TNM N
0	26	73.99 ± 9.211	0.4849	26	28.20 ± 8.763	0.7158	25	2.732 ± 0.769	0.0403
1–2	14	84.39 ± 10.49		12	23.05 ± 7.982		13	6.548 ± 2.021
TNM M
0	34	71.73 ± 6.868	0.0428	32	21.28 ± 5.175	0.0570	32	3.562 ± 0.76	0.2221
1	6	111.1 ± 22.62		6	54.80 ± 29.61		6	6.575 ± 4.071
TNM stage
Early(I/ II)	24	66.35 ± 8.097	0.0464	24	22.71 ± 6.797	0.4407	23	2.710 ± 0.836	0.0642
Advanced (III/IV)	16	94.57 ± 11.61		14	33.20 ± 13.27		15	6.072 ± 1.772
Grade
WD	8	62.62 ± 14.33	0.5367	8	37.70 ± 19.55	0.6844	8	1.52 ± 0.41	0.3173
MD	28	82.48 ± 8.83		27	23.70 ± 7.14		26	4.89 ± 1.24
PD	4	73.76 ± 16.26		3	22.84 ± 3.32		4	3.50 ± 1.59
Tumor size
⩽3 cm	18	59.38 ± 8.190	0.0087	17	25.53 ± 9.579	0.8158	17	3.853 ± 1.725	0.7530
> 3 cm	20	96.60 ± 10.38		19	28.77 ± 9.850		19

Statistical significance was defined as P < 0.05

WD Well differentiated, MD Moderately differentiated, PD Poorly differentiated