Fig. 1.

Global disruption of HSP co-expression network in cancer. a Expression correlation between mRNA level and protein level of HSP genes in BRCA samples. Red dots denote significant correlation (Rs > 0.3 and |FDR| < 0.05). Colored blocks in inner circle denote HSP family/subfamily. b Schematic diagram for HSP co-expression network in normal tissues (blue) and matched cancer types (red). Colored ovals denote number of co-expression pairs detected in normal and tumor tissues (right panel). c HSP co-expression network in normal and tumor tissues. Each pie chart denotes percentage of co-expression is cancer tissue only (red), normal tissue only (blue), shared by cancer and normal tissues (yellow), and insignificant ones (gray). The cluster was based on co-expression pattern in cancer