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. 2020 Nov 23;20:1131. doi: 10.1186/s12885-020-07589-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Time-to-event analyses for the length of the specific PFI and for OS time according to Kaplan-Meier for HCC and PDAC patients. HCC and PDAC patients were stratified for IFNL3 rs4803217 and IFNL3 rs28416813 genotypes, respectively. The probability of the absence of an event, which is progression (upper panels) or death (lower panels), is given in Kaplan-Meier graphs for each genotype for a period of 4 yrs. for HCC or 3 yrs. for PDAC as indicated. Dotted lines indicate the median specific PFIs and the median OS times. Tables list absolute and relative numbers of patients at risk (living and non-censored). A logrank test yielded a significant relationship between IFNL genotypes and disease outcome for PDAC patients (p(PFI) = 0.01, and p(OS) = 0.05, IFNL3 rs28416813 CC vs CG/GG) but not for HCC patients (p(PFI) = 0.65 and p(OS) = 0.87, IFNL3 rs4803217 CC vs CA/AA). This test was performed by comparing carriers of SNP variants that correspond to their ability to express IFNL4 (light blue and yellow) to knockout variant homozygotes (dark blue)