Table 3.

Risk factors of malignancies among all thiopurine users: univariate and multivariate Cox regression model.

	Univariate model		Multivariate model
	HR (95% CI)	p value	HR (95% CI)	p value
Age in year	1.05 (1.04–1.05)	<0.001	1.05 (1.04–1.05)	<0.001
Male sex	1.45 (1.25–1.69)	<0.001	1.24 (1.05–1.45)	0.010
Indications:
IBD	(Reference)		(Reference)
Rheumatological Disease	1.38 (0.87–2.18)	0.175	0.53 (0.32–0.88)	0.014
Post-Transplantation	2.21 (1.58–3.09)	<0.001	1.69 (1.13–2.51)	0.010
Others	1.25 (0.90–1.73)	0.185	0.91 (0.64–1.28)	0.597
Concomitant Drug Usage among all thiopurine users:
Anti-TNFs	0.33 (0.15–0.74)	0.007	0.43 (0.19–1.01)	0.054
Cyclosporin	1.32 (1.13–1.54)	<0.001	1.04 (0.84–1.30)	0.715
Methotrexate	1.31 (1.03–1.68)	0.030	2.09 (1.58–2.77)	<0.001
Tacrolimus	0.98 (0.78–1.25)	0.886	1.07 (0.82–1.40)	0.603
Mycophenolate	0.77 (0.64–0.92)	0.004	0.87 (0.72–1.09)	0.256

CI, confidence interval; HR, hazard ratio; IBD, inflammatory bowel disease; SIR, standardized incidence ratio; TNF, tumor necrosis factor.