Table 1.

Distribution of few significant SNPs in healthy controls and patients of HAPE.

S no.	Gene	rs ID	Allele	P-Value			Significant genetic models
				HAPE-p vs HAPE-f	HAPE-p vs HL	HL vs HAPE-f
1	AGT	rs69955	A/G	0.05	–	–	Co-dominant and additive model
		rs476256	G/A	–	0.024	0.03	Co-dominant and additive model
2	ACE	I/D20,50,53	I/D	≤0.05	–	–	Co-dominant and additive model
		rs806611457	C/G	0.04; 0.03	–	–	Additive model; Dominant model
		rs446114257	T/C	0.03	–	–	Dominant model
3	AGTR1	rs27565156	T/A	0.017	–	–	Additive model
		rs27565256	T/G	0.016	–	–	Additive model
4.	CYP11B2	–344T/C48	T/C	–	–	<0.0001	Additive model
		intron 2 conversion57	intron 2 conversion	–	0.03	–	Co-dominant model
5	APLN	rs3761581 25	T/G	0.0027	3.9E-05	–	Co-dominant and additive model
		rs223531225	C/T	1.0E-06	1.2E-06	–	Co-dominant and additive model
		rs311575725	C/G	0.0032	0.04	–	Co-dominant and additive model
6	APLNR	rs1154437425	G/A	0.004	–	–	Co-dominant and additive model
		rs228262325	A/G	0.013	1.0E-07	4.5E-05	Co-dominant and additive model
7	NOS3	rs179998321,25,80	G/T	0.03	1.2E-05	–	Co-dominant and additive model
		rs783025	A/C	1.6E-05	3.0E-06	–	Co-dominant and additive model
		4b/4a21,25,80	b/a	0.0003	9.0E-07	–	Co-dominant and additive model
	Gene	rs ID	Allele	Minor allele predominance
8	EPAS1	rs56721780104	G/C	Absence of minor allele C in other world population except Tibetans
		rs13419896105	G/A	Predominance of A allele in Tibetans and Sherpas
		rs149594770106	T/A	Absence of minor allele A in other world population except Tibetans
9	EGLN1	rs186996510107	G/C	Absence of minor allele C in other world population except Tibetans
		rs12097901107	C/G	Absence of minor allele G in other world population except Tibetans
				P-Value HAPE-p vs HAPE-f			Significant genetic models
		rs153866445	T/C	P < 0.008			Co-dominant and additive model
		rs47920045	G/A/C
		rs248672945	C/G/T
		rs279087945	A/C
		rs48090245	T/C
		rs248673645	C/T
		rs97325245	A/G

HAPE-p: HAPE-patients; HAPE-f: HAPE-free controls; HL: high-landers.