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. 2020 Nov 20;19:1536012120961875. doi: 10.1177/1536012120961875

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© SAGE Publications Inc. 2020

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Figure 2. — In vivo and ex vivo assessment of the aortic cross-sectional area. The Time-of-flight (TOF) angiogram of the suprarenal part of the abdominal aorta 4 weeks after continuous infusion of angiotensin II showed a strong dilatation of the aortic lumen (A1, A2) whereas a non-dilated aortic lumen was observed in mice treated with 01BSUR (A3, A4). On in vivo cross-sectional area measurements (B) and ex vivo histological measurements (C) a significant increase in cross-sectional areas of the aortic lumen size was observed in untreated mice after 4 weeks of angiotensin II infusion, reflecting development of AAAs in these mice in contrast to mice treated with 01BSUR. There was no significant difference in the cross-sectional area of the aortic lumen size between the Ang-II + 01BSUR group and the control group. In vivo MR measurements of the aortic diameter correlated strongly with ex vivo measurements on histological Elastica van Gieson (EvG) stained sections (D). aA: suprarenal abdominal-aorta; rRA: right renal-artery.