Table 1.
Comparison of tumor nodules (TN) with prostatic ductal adenocarcinoma component and pure prostatic acinar adenocarcinoma
| Variable | Outcome | PDA (n = 129) | PAA (n = 3120) | P Value |
|---|---|---|---|---|
| EPE | Yes | 92 (71.3%) | 517 (16.6%) | <.001 |
| No | 32 (24.8%) | 2519 (81%) | ||
| pT2+ | 5 (3.9%) | 75 (2.4%) | ||
| SV+ | Yes | 28 (21.7%) | 116 (3.7%) | <.001 |
| No | 100 (78.3%) | 2995 (96.3%) | ||
| SM+ | Yes | 51 (39.5%) | 296 (9.5%) | <.001 |
| No | 77 (60.5%) | 2815 (90.5%) | ||
| Volume, cm3, mean (range) | 4.26 (.22–36.11) | .84 (.004–129.45) | <.001 | |
| Gleason score (Grade Group) | 3 + 3 = 6 (1) | 0 (0) | 1930 (61.8%) | <.001** |
| 3 + 4 = 7 (2)* | 23 (17.8%) | 710 (22.8%) | ||
| 4 + 3 = 7 (3)* | 40 (31.0%) | 202 (6.5%) | ||
| 8 (4) | 7 (5.4%) | 42 (1.3%) | ||
| 9–10 (5) | 59 (45.8%) | 236 (7.6%) | ||
| Tumor nodule location | Anterior | 28 (21.7%) | 1071 (34.3%) | <.001 |
| Posterior | 57 (44.2%) | 1784 (57.2%) | ||
| Anterior to posterior | 24 (18.6%) | 211 (6.8) | ||
| Extensive bilateral | 20 (15.5%) | 54 (1.7%) |
EPE, extraprostatic extension; PAA, prostatic acinar adenocarcinoma; PDA, prostatic ductal adenocarcinoma; SM+, positive surgical margin; SV+, seminal vesicle invasion.
Cases with SM+ in the area of intraprostatic incision are staged as pT2+.
*
Tertiary pattern 5 (minor high-grade component) was present in 4 (17%) case of GS 3 + 4 = 7 and 9 (23%) case of GS 4 + 3 = 7 TNs with PDA and 38 (5.4%) and 37 (18.4%) in PAA TNs, correspondingly.
**
Only GGs 2–5 are included in analysis because PDA by definition cannot be present in GG1 TNs.