Table 3.

Generalized estimate equation: effect of prostatic ductal adenocarcinoma on EPE, SV+, and SM+

			UVA		MVA1		MVA2
Outcome	Variable	Category	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P Value
EPE	Ductal	No	Reference		Reference		Reference
		Yes	13.84 (9.10, 21.05)	0.001	.88 (.51, 1.51)	0.64	.88 (.51, 1.51)	.64
	Grade	GS6	Reference		Reference		Reference
		GS7 (3 + 4)	38.54 (25.15, 59.04)	0.001	5.90 (3.64, 9.55)	0.001	5.89 (3.64, 9.54)	.001
		GS7 (4 + 3)	104.74 (65.26, 168.09)	0.001	16.14 (9.26, 28.13)	0.001	16.14 (9.26, 28.13)	.001
		GS8+	172.07 (108.44, 273.04)	0.001	16.77 (9.83, 28.60)	0.001	17.11 (9.99, 29.31)	.001
	Log of volume	Every one unit increased	4.95 (4.31, 5.68)	0.001	3.74 (3.15, 4.42)	0.001	3.76 (3.17, 4.45)	.001
	Log Prostate Weight	Every one unit increased	.79 (.63, 1.00)	0.047	NA		.78 (.54, 1.14)	.2
	Log Pre-PSA	Every one unit increased	2.56 (2.20, 2.98)	0.001	NA		1.08 (.82, 1.42)	.57
	Log PSAD	Every one unit increased	2.49 (2.16, 2.88)	0.001	1.14 (.90, 1.45)	0.28	NA
SV+	Ductal	No	Reference		Reference		Reference
		Yes	7.19 (4.56, 11.33)	0.001	.99 (.58, 1.69)	0.98	.99 (.58, 1.69)	.98
	Grade	GS6	NE		NE		NE
		GS7 (3 + 4)
		GS7 (4 + 3)
		GS8+
	Log of volume	Every one unit increased	4.75 (3.85, 5.86)	0.001	4.52 (3.57, 5.72)	0.001	4.49 (3.48, 5.79)	.001
	Log of prostate weight	Every one unit increased	1.41 (0.91, 2.18)	0.123	NA		1.04 (0.61, 1.77)	.89
	Log of pre-PSA	Every one unit increased	3.39 (2.68, 4.29)	0.001	NA		1.02 (0.71, 1.47)	.92
	Log of PSAD	Every one unit increased	2.81 (2.19, 3.61)	0.001	1.00 (0.73, 1.37)	0.979	NA
SM	Ductal	No	Reference		Reference		Reference
		Yes	6.26 (4.31, 9.10)	0.001	.86 (.56, 1.32)	0.5	.86 (.56, 1.32)	.5
	Grade	GS6	Reference		Reference		Reference
		GS7 (3 + 4)	11.26 (7.54, 16.81)	0.001	1.89 (1.17, 3.03)	0.009	1.87 (1.16, 3.01)	.010
		GS7 (4 + 3)	20.57 (13.00, 32.55)	0.001	2.66 (1.51, 4.66)	0.001	2.64 (1.51, 4.63)	.001
		GS8+	39.09 (25.96, 58.86)	0.001	3.06 (1.78, 5.25)	0.001	3.10 (1.81, 5.30)	0.001
	Log of volume	Every one unit increased	3.00 (2.68, 3.35)	0.001	2.48 (2.15, 2.86)	0.001	2.50 (2.16, 2.89)	.001
	Log of prostate weight	Every one unit increased	0.85 (0.64, 1.15)	0.29	NA		.73 (.51, 1.06)	.1
	Log of pre-PSA	Every one unit increased	2.66 (2.19, 3.23)	0.001	NA		1.19 (.94, 1.51)	.14
	Log of PSAD	Every one unit increased	2.55 (2.12, 3.06)	0.001	1.24 (1.00, 1.53)	0.054	NA

EPE, extraprostatic extension; SM+, positive surgical margin; SV+, seminal vesicle invasion.