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SARS-CoV-2 nsp16 evolutionary changes in compared to other human coronaviruses. (a) Phylogenetic tree construction by the neighbour joining method was performed using MEGA X software, with bootstrap values being calculated from 1000 trees using amino acid sequences of nsp16, (b) Pairwise identity % plot of nsp16 CoVs amino acid sequences performed using SDT program and (c) 3D crystal structure of the nsp16 of SARS-CoV-2 (PDB ID: 7BQ7).
