Table 1.
Participant demographics and baseline characteristics
| BFKB8488A | ||||||||||||
| Abdomen | Thigh | |||||||||||
| Characteristic | Placebo | All BFKB8488A | 3 mg | 10.5 mg | 39 mg | 111 mg | 171 mg | 342 mg | 681 mg | 171 mg | 250 mg | Allparticipants |
| (n = 18) | (n = 53) | (n = 7) | (n = 6) | (n = 6) | (n = 6) | (n = 6) | (n = 6) | (n = 6) | (n = 4) | (n = 6) | (n = 71) | |
| Age (y),mean (SD) | 44.6(10.8) | 44.6(12.3) | 39.1(15.4) | 54.5(6.5) | 46.0(8.4) | 45.7(12.0) | 45.7(10.8) | 44.5(10.0) | 33.3(13.0) | 48.5(13.2) | 46.2(14.1) | 44.6(11.8) |
| Sex, female,n (%) | 1(5.6%) | 29(54.7%) | 1(14.3%) | 3(50.0%) | 4(66.7%) | 2(33.3%) | 3(50.0%) | 5(83.3%) | 2(33.3%) | 3(75.0%) | 6(100.0%) | 30(42.3%) |
| Ethnicity,Hispanic or Latino, n (%) | 8(44.4%) | 24(45.3%) | 3(42.9%) | 3(50.0%) | 3(50.0%) | 2(33.3%) | 4(66.7%) | 3(50.0%) | 3(50.0%) | 0 | 3(50.0%) | 32(45.1%) |
| Race,White | 16(88.9%) | 36(67.9%) | 4(57.1%) | 4(66.7%) | 4(66.7%) | 3(50.0%) | 5(83.3%) | 5(83.3%) | 4(66.7%) | 1(25.0%) | 6(100.0%) | 52(73.2%) |
| BMI (kg/m2),mean (SD) | 33.14(2.43) | 34.11(3.10) | 34.06(3.68) | 35.07(3.11) | 36.17(3.08) | 32.27(1.25) | 34.98(3.38) | 32.30(1.55) | 34.78(2.87) | 35.65(3.03) | 32.27(3.74) | 33.87(2.96) |
| Serumadiponectin(µg/mL), mean (SD) | 5.08(3.52) | 6.26(4.52) | 6.01(5.91) | 7.06(6.70) | 7.03(4.06) | 5.99(5.46) | 5.23(2.64) | 4.54(2.66) | 5.53(2.22) | 10.24(5.62) | 4.20(1.29) | 5.96(4.30) |
| Triglycerides (mg/dL),mean (SD) | 175.79(85.94) | 128.72(74.49) | 138.24(98.56) | 117.88(29.12) | 105.03(38.48) | 135.15(57.35) | 155.96(40.31) | 124.23(58.56) | 186.30(154.71) | 76.84(14.28) | 100.01(47.96) | 140.66(79.63) |
| HDL cholesterol (mg/dL),mean (SD) | 44.67(12.85) | 52.86(14.05) | 50.71(10.43) | 47.11(7.73) | 54.04(8.44) | 46.34(6.70) | 51.98(6.14) | 61.23(24.70) | 43.95(8.65) | 67.82(25.54) | 57.91(12.02) | 50.79(14.13) |
| LDL cholesterol (mg/dL),mean (SD) | 113.07(18.24) | 115.63(24.31) | 120.90(27.80) | 124.55(22.18) | 114.58(18.47) | 112.10(22.44) | 129.38(18.54) | 107.37(35.67) | 109.77(24.28) | 126.40(21.42) | 98.36(21.22) | 114.98(22.83) |
| Blood glucose(mg/dL), mean (SD) | 96.00(10.54) | 94.91(8.25) | 89.14(7.13) | 97.50(12.80) | 97.67(8.87) | 98.00(5.76) | 94.67(6.22) | 94.67(7.39) | 94.00(7.46) | 93.50(13.18) | 95.50(6.25) | 95.18(8.82) |
| Plasma insulin (µU/mL),mean (SD) | 9.78(4.64) | 11.01(7.49) | 7.67(3.60) | 18.30(13.77) | 10.73(9.42) | 13.14(7.23) | 8.08(2.12) | 8.00(4.11) | 13.19(5.70) | 11.90(9.02) | 8.97(4.17) | 10.70(6.87) |
| HOMA-IR, mean (SD) | 2.37(1.54) | 2.50(2.22) | 1.81(1.17) | 5.07(4.43) | 2.87(3.10) | 2.68(1.49) | 1.57(0.65) | 1.40(0.84) | 2.53(1.08) | 2.83(2.26) | 1.96(1.01) | 2.47(2.06) |
HOMA-IR, homeostatic model assessment-insulin resistance.