Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 3;117(46):29013–29024. doi: 10.1073/pnas.2005905117

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published under the PNAS license.

PMC Copyright notice

Fig. 1. — Methylation changes associated with DKD phenotypes (glycemia, albuminuria, eGFR, and eGFR slope) in whole-blood samples of the CRIC study participants. (A) Study schematics. Methylation levels of ∼800,000 loci measured by Illumina Human MethylationEPIC arrays were used to analyze the associations with DKD phenotypes (glycemia, albuminuria, eGFR, and eGFR slope) using a linear regression model. (B) Manhattan plot. The y axis is the −log₁₀ of the association P value of hemoglobin A1c and methylation. The x axis represents the genomic location of the CpG probes. n = 473 samples. (C) Manhattan plot. The y axis is the −log₁₀ of P value of albuminuria (24 h) and methylation. The x axis represents the genomic location of the CpG probes. n = 473 samples. (D) Manhattan plot. The y axis is the −log₁₀ of P value of kidney function (baseline eGFR) and methylation. The x axis represents the genomic location of the CpG probes. n = 473 samples. (E) Manhattan plot. The y axis is the −log₁₀ of P value of kidney function decline (eGFR slope) and methylation. The x axis represents the genomic location of the CpG probes. n = 410 samples.