Table 3.

Cox proportional-hazards regression: multivariable analyses

Variable	PFS		OS
	HR (95% CI)	P value	HR (95% CI)	P value
A
Pretreatment BMI trend	1.27 (1.05 to 1.54)	0.02	1.61 (1.27 to 2.05)	<0.001
Low PNI	1.34 (1.06 to 1.69)	0.01	1.65 (1.27 to 2.13)	<0.001
B
Pretreatment BMI trend	1.27 (1.01 to 1.59)	0.04	1.56 (1.21 to 2.00)	0.001
Low PNI	1.34 (1.06 to 1.70)	0.01	1.66 (1.28 to 2.15)	<0.001
C
Pretreatment BMI trend	1.10 (1.00 to 1.22)	0.05	1.19 (1.08 to 1.32)	0.001
Low PNI	1.72 (1.36 to 2.17)	<0.001	1.62 (1.25 to 2.10)	<0.001
D
Pretreatment BMI trend	1.29 (1.06 to 1.58)	0.01	1.62 (1.26 to 2.08)	<0.001
Low PNI	1.32 (1.02 to 1.70)	0.03	1.53 (1.15 to 2.03)	0.003

(A) All patients; any decrease in pretreatment BMI (reference: no decrease). (B) All patients; BMI decrease ≥2% (reference: all other patients). (C) All patients; pretreatment BMI change as a continuous variable. (D) Non-cachectic patients; any decrease in pretreatment BMI (reference: no decrease).

OS, overall survival; PFS, progression-free survival; PNI, prognostic nutritional index.