Table 4.

Risk of all cause death in 2016–2017 among patients coprescribed BZDs and opioids stratified by OME (n=31 998)

Category	OME
	<50 (reference group)	50–90	>90
	OR (P value) 95% CI	OR (P value) 95% CI	OR (P value) 95% CI
Overall population	1	1.72 (<0.001) 1.35 to 2.19	3.13 (<0.001) 2.50 to 3.92
Female	1	1.76 (<0.001) 1.25 to 2.48	3.22 (<0.001) 2.35 to 4.40
Male	1	1.68 (0.003) 1.19 to 2.37	3.04 (<0.001) 2.20 to 4.19
Age at death
18–45	1	0.90 (0.83) 0.35 to 2.31	2.31 (0.08) 0.92 to 5.85
46–65	1	2.19 (<0.001) 1.41 to 3.39	2.78 (<0.001) 1.84 to 4.18
>65	1	1.60 (0.003) 1.18 to 2.18	3.41 (<0.001) 2.57 to 4.52

Buprenorphine and methadone were excluded.

BZD, benzodiazepines/Z-drugs; OME, oral morphine equivalent.