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. 2020 Nov 19;12:11883–11895. doi: 10.2147/CMAR.S267927

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© 2020 Huang et al.

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Silencing of circSLC19A1 inhibited viability, proliferation, migration and invasion in PCa cells. (A) The expressions of circSLC19A1 and SLC19A1 in DU145 and PC3 cells transfected with or without sicircSLC19A1 were assessed by qRT-PCR, with GAPDH serving as a reference gene. (B) The viability of DU145 and PC3 cells transfected with or without sicircSLC19A1 was measured by Cell Counting Kit-8 assay. (C) Representative photos of the colony formation of DU145 and PC3 cells transfected with or without sicircSLC19A1. (D) The colony formation of DU145 and PC3 cells transfected with or without sicircSLC19A1 was evaluated by cell colony formation assay. (E) Representative photos of the migration of DU145 and PC3 cells transfected with or without sicircSLC19A1. (F) The migration of DU145 and PC3 cells transfected with or without sicircSLC19A1 was evaluated by wound healing assay. (G) Representative photos of the invasive state of DU145 and PC3 cells transfected with or without sicircSLC19A1. (H) The invasive state of DU145 and PC3 cells transfected with or without sicircSLC19A1 was evaluated by Transwell assay. ^{^^}P<0.01 and ^{^^^}P<0.001 vs siNC.

Abbreviations: sicircSLC19A1, siRNA-circSLC19A1; siNC, siRNA-negative control; qRT-PCR, quantitative reverse-transcription polymerase chain reaction.