Figure 2.

Neoadjuvant cabozantinib plus nivolumab results in dramatic immunological response in the tumor microenvironment. (A) Representative pictures of imaging mass cytometry of normal liver cores (left) and cores from surgically resected tumor samples post systemic therapy (right). Normal hepatocytes demonstrate mild CD11b positivity. Connective tissue deposition (aSMA) is higher within the tumor sample. Post-treatment core demonstrates a focus of dense immune infiltration (bottom right). (B) Results from FlowSOM clustering analysis is visualized as a heatmap and UMAP. (C) Tumor microenvironment profiles in three normal liver regions and three post-treatment tumor regions are compared. A total of 20,631 cells for normal and 39,066 cells for tumor regions are analyzed. aSMA, alpha-smooth muscle actin; DC, dendritic cells; EC, endothelial cells; Gz, granzyme B; Mono, monocytes; Vim, vimentin.