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. 2020 Nov 20;8(2):e001681. doi: 10.1136/jitc-2020-001681

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Best overall response. Spider plot (left; A+C) as per irRC and waterfall plot (right, B+D) as per RECIST 1.1 for part A (top) and part B (bottom). Best overall response (BOR) as per RECIST1.1/irRC is displayed using the following code: black represents PD/irPD, gray SD/irSD, hashed gray Pr/irPR while hashed black CR/irCR, respectively. *Nontarget lesions (NTL) still present; **target lesions (TL) and NTLs disappeared, but new lesions (NL) were present at staging; ***time of CR of TLs; NLs appeared; staging before was SD (BOR is SD). irPD, immune-related progressive disease; irPR, immune-related partial response; irSD, immune-related stable disease.