Table 3.

Physicochemical properties of tea polyphenols and the drugs evaluated in this study.

Ligand	EGCG	TF3
Molecular weight	458.37	868.8
Lipinski Rule Violations	2	3
Intestinal Absorption (%)	58.48	43.2
BBB permeability (log BB)	−2.238	−3.559
Fraction unbounded (Fu)	0.314	0.388
Total clearance (log mL/min/kg)	0.51	0.357
Hepatotoxicity	No	No
Oral rat acute toxicity (mol/kg)	2.634	2.482
Oral rat chronic toxicity (log mg/kg of bw/day)	4.077	9.52