Table 1. Summary of 12 M. bovis BCG strain isolates from 8 children in a UK cohort.
All children in this series had been immunised with the Danish 1331 M.bovis BCG strain.
| Phenotypic drug
sensitivity profile |
||||||||
|---|---|---|---|---|---|---|---|---|
| Site of BCG detection | Clinical diagnosis | Underlying
condition |
Outcome | INH | RIF | EMB | PZA | |
| Case 1 | Left axillary LN 2013 | BCG adenitis | IL12Rb1 defect | Ongoing
infection |
S | S | R | R |
| Left axillary LN 2013 | BCG adenitis | |||||||
| Gastric aspirate 2014 | Disseminated BCG | S | S | R | R | |||
| Gastric aspirate 2014 | Disseminated BCG | |||||||
| Right axillary LN 2014 | Disseminated BCG | S | S | S | R | |||
| Cervical LN 2015 | Relapse disseminated
BCG |
S | R | S | R | |||
| Pus, abdominal wall 2017 | Relapse disseminated
BCG |
S | S | S | R | |||
| Case 2 | Left axillary LN 2013 | BCG adenitis | Metabolic disorder | Resolved
infection |
S | S | S | R |
| Case 3 | Tissue L arm 2013 | BCG adenitis | Nil | Resolved
infection |
S | S | R | R |
| Axillary swab 2013 | BCG adenitis | Nil | Resolved
infection |
|||||
| Case 4 | Left axillary LN 2013 | BCG adenitis | Nil | Resolved
infection |
S | S | S | R |
| Case 5 | BCG site swab 2015 | BCG site abscess | Nil | Resolved
infection |
R | S | S | R |
| Case 6 | Left axillary LN 2007 | BCG adenitis | HIV | Resolved
infection |
S | S | S | R |
| Case 7 | Gastric aspirate/PEG swab
2009 |
Abscess over BCG scar | Nil | Resolved
infection |
S | S | S | R |
| Case 8 | BCG scar 2007 | ND | ND | ND | S | S | S | R |
Key: LN, lymph node; RIF, Rifampicin; INH, isoniazid; PZA, pyrazinamide; EMB, ethambutol; ND, No data available. Blank indicates not tested.