Table 2.
Subgroup analysis of pooled HR for OS/DFS/RFS/PFS.
| Categories | No. of studies | No. of patients | Pooled HR (95% CI) | Heterogeneity | ||
|---|---|---|---|---|---|---|
| Fix/Random | p-value | I² (%) | P-value | |||
| Cancer type | ||||||
| 1) Breast cancer | 6 | 2,148 | 1.43 (1.25–1.63) | 0.000 | 36.8 | 0.161 |
| 2) Bladder cancer | 3 | 338 | 3.90 (2.09–7.29) | 0.000 | 46.6 | 0.154 |
| 3) Others | 4 | 331 | 1.45 (0.68–3.11) | 0.339 | 64.4 | 0.038 |
| Analysis | ||||||
| 1) Multivariate | 7 | 1,007 | 2.44 (1.26–4.70) | 0.008 | 78.0 | 0.000 |
| 2) Kaplan-Meier curves | 5 | 1,515 | 1.49 (1.24–1.79) | 0.000 | 28.0 | 0.235 |
| Sample size | ||||||
| 1) ≥100 | 8 | 2,471 | 1.43 (1.25–1.62) | 0.000 | 41.1 | 0.104 |
| 2) <100 | 5 | 346 | 1.81 (0.77–4.62) | 0.175 | 72.6 | 0.006 |