TABLE 1.

RASopathy disorders and their known disease genes

RASopathy	Disease genes	Cases accounted for by known disease genes (%)
Noonan syndrome	PTPN11, SOS1, RAF1, KRAS, MRAS, NRAS, RRAS, BRAF, RIT1, SOS2, LZTR1, RASA2, RRAS, RRAS2 MAP2K1	85
NS with multiple lentigines	PTPN11, RAF1, BRAF	>90
NS-like with loose anagen hair	SHOC2, PPP1CB	100
Costello syndrome	HRAS	100
Cardiofaciocutaneous syndrome	BRAF, MAP2K1, MAP2K2, KRAS	70
Noonan-like with juvenile myelomonocytic leukemia	CBL	100

Citations for Table 1: Tidyman and Rauen (2016); Aoki et al. (2013); Yamamoto et al. (2015); Tajan, Paccoud, Branka, Edouard, and Yart (2018); Yu et al. (2019).

Bold indicates definitive or strong; non-bold indicates moderate or limited.