Fig. 2.

Reduction of Lsd1 exacerbates the PS19 Tau mouse paralysis phenotype. (A) Lifespan curve showing that no Lsd1^Δ/+ mice died before 18 mo (orange, n = 20). PS19;Lsd1^Δ/+ mice (purple, n = 44) have a significant reduction in survival compared to PS19 Tau mice with wild-type levels of Lsd1 (green, n = 37) (Log-rank Mantle–Cox test ***P < 0.005). (B–D) Rotarod testing of latency to fall (in seconds) (B), rotations per minute (when the mouse fell) (C), and distance traveled (in centimeters) (D) for mice at ages 6, 8, and 10 mo. Lsd1^Δ/+ (orange, n = 10, 11, 14), PS19 Tau (green, n = 11, 22, 9), and PS19;Lsd1^Δ/+ (purple, n = 8, 17, 11). Values are mean ± SEM (two-way ANOVA) with Tukey’s post hoc test *P < 0.05, **P < 0.01; ns, not significant.