Fig. 6.

Overexpression of LSD1 rescues the moleular changes in PS19 Tau mice. (A) Histogram (log₂ fold change) of the 144 genes that have significant changes in expression in the PS19 Tau-HA inj mice (green, n = 3) and their corresponding gene expression changes in the PS19 Tau-LSD1 inj mice (blue, n = 3). (B) Scatterplot showing the correlation between the genome-wide log₂ fold change in gene expression between PS19 Tau-HA inj and PS19 Tau-LSD1 inj. The most significantly changed genes in the PS19 Tau-HA inj mice are shown in red (up-regulated) and green (down-regulated). All other genes are shown in gray. Dotted line represents 1:1 relationship between gene expression changes in PS19 Tau-Ha inj and PS19 Tau-LSD1 inj. Rescued genes fall to the Left of the dotted line in the positively correlated quadrant and to the Right of the dotted line in the negatively correlated quadrant. Genes with correlated expression changes are found in the Top Right and Bottom Left quadrants, while genes that do not correlate are found in the opposite quadrants.