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. 2020 Nov 5;8:552020. doi: 10.3389/fcell.2020.552020

FIGURE 3.

FIGURE 3

CGA reduced intestinal damage caused by ST infection by upregulating lncRNA GAS5 expression. (A) RT-qPCR detected differential expression of lncRNAs in intestinal tissue of mice (n = 5); (B) RT-qPCR detected lncRNA GAS5 expression (n = 5); (C) HE staining detected pathology of rectum and cecum of mice (×200) (n = 5)’ the arrow points to the bleeding point; (D) spleen organ index of mice in each group (n = 5); (E) cecum organ index of mice in each group (n = 5); (F) Salmonella loads in the cecum, spleen, liver and mesenteric lymph nodes of mice (n = 5); (G) intestinal cytokine secretion level of mice in each group (n = 5); (H) daily measurement of body weight of mice in each group (n = 10); (I) survival status of each group (n = 10). The abscissa is the observation time, and the ordinate is the survival rate. Kd-GAS5 is the interference vector of GAS5, and the empty vector (kd-NC) is used as the control. The data in (B,D) were analyzed using one-way ANOVA and Tukey’s multiple comparison test, data in (A,F,G,H) were analyzed using two-way ANOVA and Tukey’s multiple comparison test, and data in (I) was analyzed using Kaplan-Meier analysis; *p < 0.05, **p < 0.01.