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. 2020 Nov 5;8:552020. doi: 10.3389/fcell.2020.552020

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Copyright © 2020 Tan, Yan, Li, Liang, Yu, Li, He, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTEN knockdown inhibited autophagy and reversed the protective effect of CGA on ST infection. The autophagy level of MODE-K cells was observed after PTEN expression was knocked down. (A) TEM was used to observe the autophagosomes and colonies of cells in each group (×5,000); (B) MDC fluorescence staining was used to detect the cellular autophagy in each group; (C) the relative expression of MDC-positive cells; (D) western blot detection for quantification of the expression of autophagy-related proteins; (E) gentamicin protection assay was used to detect the invasion rate of ST to MODE-K cells after different CGA treatments. All the experiments were repeated 3 times. The data in (A,D) were analyzed using t-test for statistical analysis, and data in panel E were analyzed using two-way ANOVA and Tukey’s multiple comparison test. Compared with ST + CGA group, *p < 0.05, **p < 0.01.