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. 2020 Nov 19;13:11957–11973. doi: 10.2147/OTT.S276559

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© 2020 Liu et al.

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Diagram presentation of the molecular mechanism. KDM3A encourages the transcription of ETS1 through the demethylation and histone modification of H3K9me2, while ETS1 further binds to the promoter region of KIF14 to promote its transcription activity, which activate the Hedgehog signaling pathway and promote CC progression.