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. Author manuscript; available in PMC: 2021 Oct 27.
Published in final edited form as: Biochemistry. 2020 Oct 15;59(42):4131–4142. doi: 10.1021/acs.biochem.0c00672

Figure 8∣. NBDY in sculpting specificity of the RNA decapping complex: a model.

Figure 8∣

NMD targets (grey) can be degraded by endonucleolytic or exonucleolytic RNA decay from either direction. Mature cytoplasmic RNAs are targeted to rapid decay by NBDY-bound (blue) or by NBDY-free (yellow) decapping complex in wild type cells. The former is stabilized and the latter destabilized in NBDY KO. Meanwhile, NMD targets and substrates of alternative decay pathways are stabilized by secondary transcriptional changes during NBDY knockout.