FIGURE 2.

Mean±sd forced vital capacity (FVC) % predicted values at 0 (baseline/treatment initiation), 1, 2 and 3 years following treatment with antifibrotics. a) Analysis based on as-observed (nonimputed) data. Data for all patients were available at 0- and 1-year time points. At 2 years, we had available data for 17 patients, as two patients had died, and 11 patients had either been lost to follow-up or had not reached this time point. At 3 years, we had available data for 14 patients, as four patients had died and 12 patients had either been lost to follow-up or had not reached this time point. FVC % pred values are normally distributed at all time points. b) Analysis after imputing measurements missing due to death. Missing FVC % pred measurements for patients who died (n=2 at 2 years and n=4 at 3 years) were imputed at a value of 30% pred, considered the lowest arbitrary value compatible with life. FVC % pred values are normally distributed at all time points.