TABLE 2.
Estimates of the annual rate of decline in forced vital capacity (FVC) % predicted and diffusing capacity of the lung for carbon monoxide (DLCO) % pred derived from linear mixed models based on the initial treatment assignment
| Patients | Estimated annual rate of decline | Baseline-adjusted estimates | |||
| 1 year | 2 years | 3 years | |||
| FVC % pred based on as-observed (nonimputed) data# | 30 | 4.2 (1.9–6.6); p=0.001 |
72.4 (68.3–76.5) |
68.2 (64.7–71.6) |
64.0 (59.6–68.3) |
| FVC % pred including data imputed due to death¶ | 30 | 7.5 (3.3–11.7); p=0.001 |
72.0 (68.1–75.9) |
64.5 (59.4–69.7) |
57.0 (48.3–65.7) |
| DLCO % pred based on as-observed (nonimputed) data+ | 24 | 5.7 (3.1–8.4); p<0.001 |
45.0 (40.9–49.2) |
39.3 (34.5–44.2) |
33.6 (26.9–40.3) |
| DLCO % pred including data imputed due to death§ | 24 | 5.8 (3.4–8.1); p<0.001 |
45.0 (41.3–48.8) |
39.3 (35.1–43.5) |
33.5 (27.8–39.3) |
Data are presented as n or % (95% CI), unless otherwise stated. #: linear mixed model using random intercept and slope with unstructured covariance matrix; ¶: linear mixed model using random intercept and slope with compound symmetry covariance matrix; six measurements (n=2 at 2 years and n=4 at 3 years) were imputed to 30% due to death; +: linear mixed model using random intercept and slope with Toeplitz covariance matrix; §: linear mixed model using random intercept and slope with Toeplitz covariance matrix; n=1 measurement at 3 years was imputed to 15% due to death.