FIGURE 1.

Patient disposition. Flow chart of the participants. Seven healthy prematurely (HP) born infants could not be located for the study. However, one subject, who was not measured in infancy, could be included in the adult group. Three refused to participate and one moved abroad leaving 14 HP participants. Of the hyaline membrane disease (HMD) subjects, 5 could not be located at adult age leaving 14 HMD participants. Of those with bronchopulmonary dysplasia (BPD), 2 passed away during infancy, 2 could not be located, 2 have moved abroad, 3 refused to participate and 3 were severely mentally handicapped, precluding them to participate at adulthood leaving 36 BPD participants. As clinical data of HP and HMD groups revealed no differences (supplementary table S1), all data of these two groups were combined to qualify as non-BPD (non-BPD, n=28). Thus, in total, 28 non-BPD served as controls and 36 BPD subjects were analysed in the study. All HP subjects were White except for one from Indonesia and two from North African, one HMD and one BPD subject was from Indonesia.