TABLE 3.
Regression analysis of perinatal parameters on outcomes in adult BPD
| zFEV1/FVC | zFEV1 | zDLCO | SMS | SGRQ | |
| FIO2 36w (B (p)) | −3.2 (0.29) | −6.4 (0.053) | −4.1 (0.023) | −2.4 (0.36) | 3.7 (0.86) |
| Prenatal dexa (B (p)) | −0.64 (0.24) | 0.19 (0.74) | 0.56 (0.069) | −0.77 (0.097) | 4.2 (0.27) |
| Birthweight g (B (p)) | −0.0023 (0.0091) | −0.0015 (0.089) | 0.0097 (0.043) | 0.0014 (0.075) | 0.0065 (0.28) |
| PIPmax (B (p)) | 0.028 (0.51) | 0.028 (0.53) | 0.0020 (0.93) | −0.020 (0.55) | −0.093 (0.74) |
| R2 adjusted (adjusted p-values of likelihood ratio test) | 0.20 (0.046) | 0.16 (0.081) | 0.17 (0.057) | 0.13 (0.10) | −0.057 (0.67) |
Multiple linear regression analyses were used to determine whether neonatal parameters correlated with outcomes at adult age within the BPD group. None of the dependent variables at adulthood reached a significance level, set at p<0.0025 by Bonferroni correction. zFEV1/FVC, zFEV1, zFVC, are z-scores for adult lung function outcomes with GLI-references and zDLCO with European Community of Coal and Steel references. Prenatal dexa: ante partum dexamethasone administered to mothers (yes=1, no=0). BPD: bronchopulmonary dysplasia; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; SMS: standard mass score for lung density; SGRQ: St. George's Respiratory Questionnaire; FIO2 36w: fractional inspired oxygen concentration in ambient air at post-conceptional age of 36 weeks; PIPmax: maximum positive inspiratory pressure during mechanical ventilation in cmH2O; DLCO: diffusing capacity of the lung for carbon monoxide.