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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Eur J Endocrinol. 2020 Oct;183(4):R107–R117. doi: 10.1530/EJE-20-0103

Figure 3.

Figure 3.

Imprinting pattern of maternally imprinted, paternally expressed genes MKRN3 and DLK1. A. Maternal allele is imprinted, or silenced; mutant paternal allele is expressed, resulting in phenotype of central precocious puberty. B. Maternal allele is normally imprinted and normal paternal allele is expressed, resulting in normal puberty. C. Maternal allele containing mutation is imprinted; normal paternal allele is expressed, resulting in no pathologic phenotype (i.e., normal puberty). Adapted from (103).