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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Cytotherapy. 2020 Mar 25;22(5):291–300. doi: 10.1016/j.jcyt.2020.01.013

Figure 5.

Figure 5.

TGI formulations were optimized using the differential evolution for multi-objective (DEMO) algorithm to maximize helper T-cell and cytotoxic t-cell recovery. Best performing solution compositions for each generation are shown in black (a) Post-thaw recoveries of helper T-cell (CD3+CD4+) using TGI formulations from Generation 0 to Generation 3. (b) Post-thaw recoveries of cytotoxic (CD3+CD8+) T-cells using TGI formulations from Generation 0 to Generation 3. (c) Post-thaw recoveries of CD4+ and CD8+ to TGI formulations generated via DEMO from Generation 0 to Generation 3. (d) Post-thaw recoveries of NKT (CD3+CD56+) cells in TGI formulations from Generation 0 to Generation 3.